Standard 5.1

Timing and coordination of specific events are necessary for the normal development of an organism, and these events are regulated by a variety of mechanisms.

Performance indicators:

a. Connect concepts in and across domains to show that timing and coordination of specific events are necessary for normal development in an organism and that these events are regulated by multiple mechanisms. [SP 7.2]
b. Use a graph or diagram to analyze situations or solve problems (quantitatively or qualitatively) that involve timing and coordination of events necessary for normal development in an organism. [SP 1.4]
c. Justify scientific claims with scientific evidence to show that timing and coordination of several events are necessary for normal development in an organism and that these events are regulated by multiple mechanisms. [SP 6.1]
d. Describe the role of programmed cell death in development and differentiation, the reuse of molecules, and the maintenance of dynamic homeostasis. [SP 7.1]
e. Justify scientific claims with evidence to show how timing and coordination of physiological events involve regulation. [SP 6.1]
f. Connect concepts that describe mechanisms that regulate the timing and coordination of physiological events. [SP 7.2]

Class Activities:

Hox Gene Coloring

From WGBH. Can not legally be posted in public webspace.


Standard 5.2

Interactions between external stimuli and regulated gene expression result in specialization of cells, tissues and organs.

Performance indicators:

a. Refine representations to illustrate how interactions between external stimuli and gene expression result in specialization of cells, tissues and organs. [SP 1.3]

Class Activities:

Plant Hormones POGIL

Can not legally be posted in public webspace.


Standard 5.3

Organisms use feedback mechanisms to maintain their internal environments and respond to external environmental changes.

Performance indicators:

a. Justify a claim made about the effect(s) on a biological system at the molecular, physiological or organismal level when given a scenario in which one or more components within a negative regulatory system is altered. [SP 6.1]
b. Connect how organisms use negative feedback to maintain their internal environments. [SP 7.2]
c. Evaluate data that show the effect(s) of changes in concentrations of key molecules on negative feedback mechanisms. [SP 5.3]
d. Make predictions about how organisms use negative feedback mechanisms to maintain their internal environments. [SP 6.4]
e. Make predictions about how positive feedback mechanisms amplify activities and processes in organisms based on scientific theories and models. [SP 6.4]
f. Justify that positive feedback mechanisms amplify responses in organisms. [SP 6.1]

Class Activities:

Feedback Loops POGIL

Can not be legally posted in public webspace.

Maintenance Physiology Info Cooperative Project



Standard 5.4

Homeostatic mechanisms reflect both common ancestry and divergence due to adaptation in different environments.

Performance indicators:

a. Construct explanations based on scientific evidence that homeostatic mechanisms reflect continuity due to common ancestry and/or divergence due to adaptation in different environments. [SP 6.2]
b. Analyze data to identify phylogenetic patterns or relationships, showing that homeostatic mechanisms reflect both continuity due to common ancestry and change due to evolution in different environments. [SP 5.1]
c. Connect differences in the environment with the evolution of homeostatic mechanisms. [SP 7.1]

Class Activities:

Maintenance Physiology Info Cooperative Project



Standard 5.5

Biological systems are affected by disruptions to their dynamic homeostasis.

Performance indicators:

a. Use representations or models to analyze quantitatively and qualitatively the effects of disruptions to dynamic homeostasis in biological systems. [SP 1.4]

Class Activities:

Maintenance Physiology Info Cooperative Project



Standard 5.6

Plants and animals have a variety of chemical defenses against infections that affect dynamic homeostasis.

Performance indicators:

a. Create representations and models to describe immune responses. [SP 1.1, 1.2]
b. Create representations or models to describe nonspecific immune defenses in plants and animals.[SP 1.1, 1.2]

Class Activities:

Immune System POGIL

Can not be legally posted in public webspace.


Standard 5.7

Timing and coordination of behavior are regulated by various mechanisms and are important in natural selection.

Performance indicators:

a. Analyze data to support the claim that responses to information and communication of information affect natural selection. [SP 5.1]
b. Justify scientific claims, using evidence, to describe how timing and coordination of behavioral events in organisms are regulated by several mechanisms. [SP 6.1]
c. Connect concepts in and across domain(s) to predict how environmental factors affect responses to information and change behavior. [SP 7.2]

Class Activities:

Plant Hormones POGIL

Can not be legally posted in public webspace.